Publications
56
New Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art. Trimpin, S.,* Yenchick, F. S., Lee, C., Hoang, K., Pophristic, M., Karki, S., Marshall, D. D., Lu, I. C., Lutomski, C. A., El-Baba, T. J., Wang, B., Pagnotti, V. S., Meher, A. K., Chakrabarty, S., Imperial, L. F., Madarshahian, S., Richards, A. L., Lietz, C. B., Moreno-Pedraza, A., Leach, S. M., Gibson, S. C., Elia, E. A., Thawoos, E. M., Woodall, D. W., Jarois, D. R., Davis, E. T. J., Liao, G., Muthunayake, N. S., Redding, M. J., Reynolds, C. A., Anthony, T. M., Vithanarachchi, S. M., DeMent, P., Adewale, A. O., Yan, L., Wager-Miller, J., Ahn, Y. H., Sanderson, T. H., Przyklenk, K., Greenberg, M. L., Suits, A. G., Allen, M. J., Narayan, S. B., Caruso, J. A., Stemmer, P. M., Nguyen, H. M., Weidner, S. M. M., Rackers, K. J., Djuric, A., Shulaev, V., Hendrickson, T. L., Chow, C. S., Pflum, M. K. H., Grayson, S. M., Lobodin, V. V., Guo, Z., Ni, C. K., Walker, J. M., Mackie, K., Inutan, E. D., McEwen, C. N. J. Am. Soc. Mass Spectrom. 2024, 35, 2753-2784. Link
55
A Perspective on a promising role for caffeine in modulating the calcium-sensing receptor in pancreatic beta-cells. Younis, M. Y. G,* Matarage Don, N. N. J., Ahn, Y. H.* IOSR J. Dent. Med. Sci. 2024, 23, 12-18. Link.
54
Protein phosphatase PP2Cα S-glutathionylation regulates cell migration. Kukulage D. S. K., Samarasinghe, K. T. G., Matarage Don, N. N. J., Shivamadhu, M. C., Shishikura, K., Mashhad Ramezani, F., Schiff, W., Padmavathi, R., Matthews, M. L., Ahn, Y. H.* J. Biol. Chem. 2024, 300, 107784. Link. Selected as an Editor's Pick & Highlighting the first author.
53
Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor. Matarage Don, N. N. J., Padmavathi, R., Khasro, T. D., Zaman, M. R. U., Ji, H. F., Ram, J. L., Ahn, Y. H.* ACS Chem. Biol. 2024, link, Highlighting the first author by Journal.
52
A Homogeneous Time-Resolved Fluorescence Screen to Identify SIRT2 Deacetylase and Defatty-Acylase Inhibitors. Yang, J., Cassel, J., Boyle, B. C., Oppong, D., Ahn, Y. H., Weiser, B. P.* PLOS ONE, 2024, 19, e0305000. Link.
51
Clickable Glutathione-based Identification of Cysteine Glutathionylation. Matarage Don, N. N. J., Kukulage, D. S. K., Ahn, Y. H.* Curr Protoc. 2023, 10, e907. Link.
50
Chemoproteomic Strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration. Kukulage, D. S. K.,# Yapa Abeywardana, M.,# Matarage Don, N. N. J., Hu, R. -H., Shishikura, K., Matthews, M. L., Ahn, Y. H.* Cell Chem. Biol. 2023, 30, 1542-1556. # equal contribution. Link. Highlighted in Cell Chem Biol, Link
49
Chemistry and Biology of Enzymes in Protein Glutathionylation. Oppong, D., Schiff, W., Shivamadhu, M. C., Ahn, Y. H.* Curr. Opin. Chem. Biol. 2023, 75, 102326. Link
48
Emerging Chemistry and Biology in Protein Glutathionylation. Kukulage, D. S. K., Matarage Don, N. N. J., Ahn, Y. H.* Curr. Opin. Chem. Biol. 2022, 71, 102221. Link
47
Bach derepression is neuroprotective in mouse model of Parkinson’s disease, Ahuja, M., Kaidery, N. A., Attucks, O. C., McDade, E., Hushpulian, D. M., Gaisin, A., Gaisina, I., Ahn, Y. H., Nikulin, S., Poloznikov, A., Gazaryan, I., Yamamoto, M., Matsumoto, M., Igarashi, K., Sharma, S. M. Thomas, B. Proc. Natl. Acad. Sci. USA. 2021, 118, e2111643118. Link
46
Identification and Quantification of Glutathionylated Cysteines under Ischemic Stress, Yapa Abeywardana, M., Samarasinghe, K. T. G., Munkanatta Godage, D., Ahn, Y. H.* J. Proteome Res. 2021, 20, 4529-4542. Link
45
Titin N2A Domain and Its Interactions at the Sarcomere, Adewale, A. O., Ahn, Y. H. Int. J. Mol. Sci. 2021, 22, 7563. Link
44
Synthesis and Evaluation of Tiaprofenic Acid-derived UCHL5 Deubiquitinase Inhibitors, Gurusingha Arachchige, H. S., Herath Mudiyanselage, P. D. H., VanHeck, G. C., Patel, K., Cheaito, H. A., Dou, Q. P., Ahn, Y. H.* Bioorg. Med. Chem. 2021, 30, 115931. Link
43
The isothiocyanate sulforaphane inhibits mTOR in an Nrf2-independent manner, Zhang, Y., Gilmour, A., Ahn, Y. H., de la Vega, L., Dinkova-Kostova, A. T. Phytomedicine 2021, 86, 153062. Link
42
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells, Zhang, Y., VanHecke, G. C., Ahn, Y. H., Proby, C. M., Dinkova-Kostova, A. T. Eur. J. Pharmacol. 2020, 889, 173609. Link
41
Isotopically-labelled Clickable Glutathione to Quantify Protein S-Glutathionylation, VanHecke, G. C.,ª Yapa Abeywardana, M.,ª Huang, B., Ahn, Y. H. ChemBioChem, 2020, 21, 853-859. ªequal contribution. Link. Selected as Very Important Paper by ChemBioChem
40
Proteomic Identification of Protein Glutathionylation in Cardiomyocytes, VanHecke, G. C., Yapa Abeywardana, M., Ahn, Y. H. J. Proteome Res. 2019, 18, 1806-1818. Link
39
Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds, Castro, I., Ekinic, E., Huang, X., Cheaito, H. A., Ahn, Y. H., Olivero-Verbel, J., Dou, Q. P. J. Cell. Biochem. 2019, 120, 14065-14075. Link
38
SMYD2 Glutathionylation Contributes to Degradation of Sarcomeric Proteins. Munkanatta Godage, D. N. P., VanHecke, G. C., Samarasinghe, K. T. G., Feng, H. Z., Hiske, M., Holcomb, J., Yang, Z., Jin, J. -P., Chung, C. S., Ahn, Y. H.* Nature Commun. 2018, 9, 4341. Link
37
Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition. Patel, K., Ahmed, Z. S. O., Huang, X., Yang, Q., Barzegar, E. E., Neslund-Dudas, C. M., Mitra, B., Elnady, F. A. E. M., Ahn, Y. H., Yang, H., Liu, J., Dou, Q. Future Med. Chem. 2018, 10, 2087-2108. Link
36
Redox-inactive peptide disrupting Trx1-Ask1 interaction for selective activation of stress signaling. Kekulandara, D. N., Nagi, S., Seo, H., Chow, C. S., Ahn, Y. H.* Biochemistry 2018, 57, 772–780. Link
35
Sphingosine-1-phosphate receptor subtype 3 regulates TGF-β-mediated Sani1/E-cadherin pathway and lung adenocarcinoma progression. Zhao, J., Liu, J., Lee, J. F., Zhang, W., VanHecke, G. C., Gartung, A., Gauldie, J., Ahn, Y. H., Lee, M. J. J. Biol. Chem. 2016, 291, 27343-27353. Link
34
Clickable glutathione using tetrazine-alkene bioorthogonal chemistry for detecting protein glutathionylation. Kekulandara, D. N., Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Ahn, Y. H.* Org. Biomol. Chem. 2016, 14, 10886-10893. Link
33
Characterization of eicosanoids produced by adipocyte lipolysis: implication of cyclooxygenase-2 in adipose inflammation. Gartung, A., Zhao, J., Chen, S., Mottillo, E., VanHecke, G. C., Ahn, Y. H., Maddipati, K. R., Sorokin, A., Granneman, J., Lee, M. J. Biol. Chem. 2016, 291, 16001-16010. Link
32
Identification of protein glutathionylation in response to glucose metabolism. Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Zhou, Y., Ndombera, F. T., Weerapana, E., Ahn, Y. H. Mol. Biosyst. 2016, 12, 2471-2480. Link
31
Carbohydrate-based Inducers of Cellular Stress for Targeting Cancer Cells. Ndombera, F. T., VanHecke, G. C., Nagi, S., Ahn, Y. H. Bioorganic. Med. Chem. Lett. 2016, 26, 1452-1456. Link
30
YcgC Represents a New Protein Deacetylase Family in Prokaryote. Tu, Shun., Guo, S. J., Chen, C. S., Liu, C. X., Jiang, H. W., Ge, F., Deng, J. Y., Zhou, Y. M., Czajkowsky, D., Li, Y., Cole, P. A., Ahn, Y. H., Zhu, H., Tao, S. C. eLife, 2015, 4, e05322. Link
29
Synthesizing Clickable Glutathione by Glutathione Synthetase Mutant for Detecting Protein Glutathionylation. Samarasinghe, K. T. G., Ahn, Y. H. SynLett. 2015, 26, 285-293. Link
28
A Versatile New Tool to Label Abasic Sites in DNA and Inhibit Base Excision Repair. Wei, S., Shalhout, S., Ahn, Y. H., Bhagwat, A. S. DNA Repair, 2015, 27, 9-18. Link
27
Adipocyte Lipolysis-stimulated Interleukin-6 Production Regulates Sphingosine Kinase 1 Activity. Zhang, W., Mottillo, E. P., Zhao, J., Gartung, A., VanHecke, G. C., Lee, J. F., Maddipati, K. R., Xu, H., Ahn, Y. H., Prola, R. L., Granneman, J. G., Lee, M. J. J. Biol. Chem. 2014, 289, 32178-32185. Link
26
Metabolic Synthesis of Clickable Glutathione for Chemoselective Detection of Glutathionylation, Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., VanHecke, G. C., Ahn, Y. H. J. Am. Chem. Soc. 2014, 136, 11566-11569. Link
25
Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. Zhang, Y., Naidu, S. D., Samarasinghe, K., VanHecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. B., Cole, P. A., Ahn, Y. H., Dinkova-Kostova, A. T. Br. J. Cancer. 2014, 110, 71-82. Link
24
An Fc Domain Protein-Small Molecule Conjugate as an Enhanced Immunomodulator. Chiang, M. J., Hobert, M. A., Kalin, J. H., Ahn, Y. H., Giddens, J., Amin, M. N., Taylor, M. S., Collins, S. L., Chan-Li, Y., Waickman, A., Hsiao, P. Y., Bolduc, D., Leahy, D. J., Horton, M. R., Wang, L. X., Powell, J. D., Cole, P. A. J. Am. Chem. Soc. 2014, 136, 3370-3373. Link
23
Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Dancy, B. M., Crump, N. T., Peterson, D. J., Mukherjee, C., Bowers, E. M., Ahn, Y. H., Yoshida, M., Zhang, J., Mahadevan, L. C., Meyers, D. J., Boeke, J. D., Cole, P. A. Chembiochem. 2012, 13, 2113-2121. Link
22
HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Zhang, Y., Ahn, Y. H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A., Dinkova-Kostova, A. T. Chem. Biol. 2011, 18, 1355-1361. Link
21
Development of Neh2-Luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Smirnova, N. A., Haskew-Layton, R. E., Manuela, B., Hushpulian, D. M., Payappilly, J. B., Speer, R. E., Ahn, Y. H., Rakhman, I., Cole, P. A., Pinto, J. T., Ratan, R. R., Gazaryan, I. G. Chem. Biol. 2011, 18, 752-765. Link
20
Hyaluronan Fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor. Collins, S. L., Black, K. E., Chan-Li, Y., Ahn, Y. H., Cole, P. A., Powell, J. D., Horton, M. R. Am. J. Respir. ​Cell. Mol. Biol. 2011, 45, 675-683. Link
19
Bodipy-diacrylate imaging probes for targeted proteins inside live cells. Lee, J. J., Lee, S. C., Zhai, D., Ahn, Y. H., Yeo, H. Y., Tan, Y. L., Chang, Y. T. Chem. Commun. 2011, 47, 4508-4510. Link
18
The binding of fluorophores to proteins depends on the cellular environment. Kim, Y. K., Lee, J. S., Bi. X., Ha, H. H., Ng, S. H., Ahn, Y. H., Lee, J. J., Wagner, B. K., Clemons, P. A., Chang, Y. T. Angew. Chem. Int. Ed. Engl. 2011, 50, 2761-2763. Link
17
Electrophilic tuning of the chemoprotective natural product sulforaphane. Ahn, Y. H., Hwang, Y., Liu, H.; Wang, X. J., Zhang, Y., Stephenson, K. K., Boronina, T. N., Cole, R. N., Dinkova-Kostova, A. T., Talalay, P., Cole, P. A. Proc. Natl. Acad. Soc. USA. 2010, 107, 9590-9595. Link
16
A fluorescent rosamine compound selectively stains pluripotent stem cells. Im, C. N., Kang, N. Y., Ha, H. H., Bi, X., Lee, J. J., Park, S. J., Lee, S. Y., Vendrell, M., Kim, Y. K., Lee, J. S., Li, J., Ahn, Y. H., Feng, B., Ng, H. H., Yun, S. W., Chang, Y. T. Angew. Chem. Intl. Ed. Engl. 2010, 49, 7497-7500. Link
15
Combinatorial synthesis of a triphenylmethine library and their application in the development of surface enhanced Raman scattering (SERS) probes. Cho, S. J., Ahn, Y. H., Maiti, K. K., Dinish, U. S., Fu, C. Y., Thoniyot, P., Olivo, M., Chang, Y. T. Chem. Commun. 2010, 46, 722-724. Link
14
Control of muscle differentiation by a mitochondria-targeted fluorophore. Kim, Y. K., Ha, H. H., Lee, J. S., Bi, X., Ahn, Y. H., Hajar, S., Lee, J. J., Chang, Y. T. J. Am. Chem. Soc. 2010, 132, 576-579. Link
13
Selective human serum albumin sensor from the screening of a fluorescent rosamine library. Ahn, Y. H., Lee, J. S., Chang, Y. T. J. Combi. Chem. 2008, 10, 376-380. Link
12
Small molecule fluorophores to detect cell-state switching in the context of high-throughput screening. Wagner, B. K., Carrinski, H., Ahn, Y. H., Kim, Y. K., Gilbert, T. J., Fomina, D., Schreiber, S. L., Chang, Y. T., Clemons, P. A. J. Am. Chem. Soc. 2008, 130, 4208-4209. Link
11
Styryl-based potential in vivo imaging agents for beta-amyloid plaques. Li, Q., Min, J., Ahn, Y. H., Namm, J., Kim, E. M., Lui, R., Ji, Y., Wu, Z. H., Wisniewski, T., Chang, Y. T. Chembiochem 2007, 8, 1679-1687. Link
10
Combinatorial synthesis of dapoxyl dyes and application to site-selective probe for human serum albumin. Min, J., Lee, J. W., Ahn, Y. H., Chang, Y. T. J. Combi. Chem. 2007, 9, 1079-1083. Link
9
Tagged small molecule library approach for facilitated chemical genetics. Ahn, Y. H., Chang, Y. T. Acc. Chem. Res. 2007, 40, 1025-1033. Link
8
Combinatorial rosamine library and application to in vivo glutathione probe. Ahn, Y. H., Lee, J. S., Chang, Y. T. J. Am. Chem. Soc. 2007, 129, 4510-4511. Link
7
RNA-selective, live cell imaging probes for studying nuclear structure and function. Li, Q., Kim, Y. K., Namm, J., Kulkarni, A., Rosania, G., Ahn, Y. H., Chang, Y. T. Chem. Biol. 2006, 13, 615-623. Link
6
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. Chi, Y., Zhou, B., Wang, W. Q., Chung, S. K., Kwon, Y. U., Ahn, Y. H., Chang, Y. T., Tsujishita, Y., Hurley, J. H., Zhang, Z. Y. J. Biol. Chem. 2004, 279, 44987-44995. Link
5
Molecular evolution using intramolecular acyl migration on myo-inositol benzoates with thermodynamic and kinetic selectors. Ahn, Y. H., Chang, Y. T. Chem. Eur. J. 2004, 10, 3543-3547. Link
4
Molecular evolution on chiro-inositol dibenzoate using intramolecular acyl migration and selection by phenyl boronic acid. Ahn, Y. H., Chang, Y. T. J. Combi. Chem. 2004, 6, 293-296. Link
3
A study on the effect of lanthanide ion coordination on the stereoselective synthesis of β-mannopyranosides. Ahn, Y. H., Chung, S. K. Kor. Chem. Soc. 2003, 24, 116-118. Link
2
A study of benzene 1,2,4-trisphosphate derivatives as inositol 1,4,5-trisphosphate 3-kinase inhibitors. Ahn, Y. H., Chung, S. K. Kor. Chem. Soc. 2002, 23, 515-517. Link
1
A novel DAST-induced debenzylative cycloetherization in D-1,2-O-isopropylidene-3,4,5-tri-O-benzyl-myo-inositol. Chung, S. K., Kwon, Y. U., Ahn, Y. H., Jeong, T. H., Chang, Y. T. Kor. Chem. Soc. 2000, 21, 274-276. Link