top of page
Publication 2.jpg



Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor. Matarage Don, N. N. J., Padmavathi, R., Khasro, T. D., Zaman, M. R. U., Ji, H. F., Ram, J. L., Ahn, Y. H.* ACS Chem. Biol. 2024, link

Graphical Abstract ACS ChemBiol 2024.jpg


A Homogeneous Time-Resolved Fluorescence Screen to Identify SIRT2 Deacetylase and Defatty-Acylase Inhibitors. Yang, J., Cassel, J., Boyle, B. C., Oppong, D., Ahn, Y. H., Weiser, B. P.* PLOS ONE, 2024, accepted.  



Clickable Glutathione-based Identification of Cysteine Glutathionylation. Matarage Don, N. N. J., Kukulage, D. S. K., Ahn, Y. H.* Curr Protoc. 2023, 10, e907. Link

Graphical Abstract Web.jpg


Chemoproteomic Strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration. Kukulage, D. S. K.,# Yapa Abeywardana, M.,# Matarage Don, N. N. J., Hu, R. -H., Shishikura, K., Matthews, M. L., Ahn, Y. H.* Cell Chem. Biol. 2023, # equal contribution. Link

Graphical Abstract for Web3.jpg


Chemistry and Biology of Enzymes in Protein Glutathionylation. Oppong, D., Schiff, W., Shivamadhu, M. C., Ahn, Y. H.* Curr. Opin. Chem. Biol. 2023, 75, 102326. Link

2023 COCB 1500 x 500.tif


Emerging Chemistry and Biology in Protein Glutathionylation. Kukulage, D. S. K., Matarage Don, N. N. J., Ahn, Y. H.* Curr. Opin. Chem. Biol. 2022, 71, 102221. Link

2022 COCB Ed1.tif


Bach derepression is neuroprotective in mouse model of Parkinson’s disease, Ahuja, M., Kaidery, N. A., Attucks, O. C., McDade, E., Hushpulian, D. M., Gaisin, A., Gaisina, I., Ahn, Y. H., Nikulin, S., Poloznikov, A., Gazaryan, I., Yamamoto, M., Matsumoto, M., Igarashi, K., Sharma, S. M. Thomas, B. Proc. Natl. Acad. Sci. USA. 2021, 118, e2111643118. Link



Identification and Quantification of Glutathionylated Cysteines under Ischemic Stress, Yapa Abeywardana, M., Samarasinghe, K. T. G., Munkanatta Godage, D., Ahn, Y. H. J. Proteome Res. 2021, 20, 4529-4542. Link

Graphical Abstract.jpg


Titin N2A Domain and Its Interactions at the Sarcomere, Adewale, A. O., Ahn, Y. H. Int. J. Mol. Sci. 2021, 22, 7563. Link



Synthesis and Evaluation of Tiaprofenic Acid-derived UCHL5 Deubiquitinase Inhibitors, Gurusingha Arachchige, H. S., Herath Mudiyanselage, P. D. H., VanHeck, G. C., Patel, K., Cheaito, H. A., Dou, Q. P., Ahn, Y. H. Bioorg. Med. Chem. 2021, 30, 115931. Link

2021 BMC Ed.tif


The isothiocyanate sulforaphane inhibits mTOR in an Nrf2-independent manner, Zhang, Y., Gilmour, A., Ahn, Y. H., de la Vega, L., Dinkova-Kostova, A. T. Phytomedicine 2021, 86, 153062. Link



Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells, Zhang, Y., VanHecke, G. C., Ahn, Y. H., Proby, C. M., Dinkova-Kostova, A. T. Eur. J. Pharmacol. 2020, 889, 173609. Link



Isotopically-labelled Clickable Glutathione to Quantify Protein S-Glutathionylation, VanHecke, G. C.,ª Yapa Abeywardana, M.,ª Huang, B., Ahn, Y. H. ChemBioChem, 2020, 21, 853-859. ªequal contribution. Link

2020 ChemBioChem Ed.tif


Proteomic Identification of Protein Glutathionylation in Cardiomyocytes, VanHecke, G. C., Yapa Abeywardana, M., Ahn, Y. H. J. Proteome Res. 2019, 18, 1806-1818. Link

2019 JPR Ed.tif


Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds, Castro, I., Ekinic, E., Huang, X., Cheaito, H. A., Ahn, Y. H., Olivero-Verbel, J., Dou, Q. P. J. Cell. Biochem. 2019, 120, 14065-14075. Link



SMYD2 Glutathionylation Contributes to Degradation of Sarcomeric Proteins. Munkanatta Godage, D. N. P., VanHecke, G. C., Samarasinghe, K. T. G., Feng, H. Z., Hiske, M., Holcomb, J., Yang, Z., Jin, J. -P., Chung, C. S., Ahn, Y. H.  Nature Commun. 2018, 9, 4341. Link



Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition. Patel, K., Ahmed, Z. S. O., Huang, X., Yang, Q., Barzegar, E. E., Neslund-Dudas, C. M., Mitra, B., Elnady, F. A. E. M., Ahn, Y. H., Yang, H., Liu, J., Dou, Q.  Future Med. Chem. 2018, 10, 2087-2108. Link



Redox-inactive peptide disrupting Trx1-Ask1 interaction for selective activation of stress signaling. Kekulandara, D. N., Nagi, S., Seo, H., Chow, C. S., Ahn, Y. H.  Biochemistry 2018, 57, 772–780. Link

2016 Biochemistry Ed.tif


Sphingosine-1-phosphate receptor subtype 3 regulates TGF-β-mediated Sani1/E-cadherin pathway and lung adenocarcinoma progression. Zhao, J., Liu, J., Lee, J. F., Zhang, W., VanHecke, G. C., Gartung, A., Gauldie, J., Ahn, Y. H., Lee, M. J.  J. Biol. Chem. 2016, 291, 27343-27353. Link



Clickable glutathione using tetrazine-alkene bioorthogonal chemistry for detecting protein glutathionylation. Kekulandara, D. N., Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Ahn, Y. H. Org. Biomol. Chem. 2016, 14, 10886-10893. Link

2018 OBC Ed1.tif


Characterization of eicosanoids produced by adipocyte lipolysis: implication of cyclooxygenase-2 in adipose inflammation. Gartung, A., Zhao, J., Chen, S., Mottillo, E., VanHecke, G. C., Ahn, Y. H., Maddipati, K. R., Sorokin, A., Granneman, J., Lee, M.  J. Biol. Chem. 2016, 291, 16001-16010. Link



Identification of protein glutathionylation in response to glucose metabolism. Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Zhou, Y., Ndombera, F. T., Weerapana, E., Ahn, Y. H. Mol. Biosyst. 2016, 12, 2471-2480. Link

2016 MolBiosys Ed.tif


Carbohydrate-based Inducers of Cellular Stress for Targeting Cancer Cells. Ndombera, F. T., VanHecke, G. C., Nagi, S., Ahn, Y. H. Bioorganic. Med. Chem. Lett. 2016, 26, 1452-1456. Link

2016 BMLC Ed.tif


YcgC Represents a New Protein Deacetylase Family in Prokaryote. Tu, Shun., Guo, S. J., Chen, C. S., Liu, C. X., Jiang, H. W., Ge, F., Deng, J. Y., Zhou, Y. M., Czajkowsky, D., Li, Y., Cole, P. A., Ahn, Y. H., Zhu, H., Tao, S. C.  eLife, 2015, 4, e05322. Link



Synthesizing Clickable Glutathione by Glutathione Synthetase Mutant for Detecting Protein Glutathionylation. Samarasinghe, K. T. G., Ahn, Y. H.  SynLett. 2015, 26, 285-293. Link



A Versatile New Tool to Label Abasic Sites in DNA and Inhibit Base Excision Repair.  Wei, S., Shalhout, S., Ahn, Y. H., Bhagwat, A. S. DNA Repair, 2015, 27, 9-18. Link



Adipocyte Lipolysis-stimulated Interleukin-6 Production Regulates Sphingosine Kinase 1 Activity. Zhang, W., Mottillo, E. P., Zhao, J., Gartung, A., VanHecke, G. C., Lee, J. F., Maddipati, K. R., Xu, H., Ahn, Y. H., Prola, R. L., Granneman, J. G., Lee, M. J.  J. Biol. Chem. 2014, 289, 32178-32185. Link



Metabolic Synthesis of Clickable Glutathione for Chemoselective Detection of Glutathionylation, Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., VanHecke, G. C., Ahn, Y. H.  J. Am. Chem. Soc. 2014, 136, 11566-11569. Link

2014 JACS Ed1.tif


Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. Zhang, Y., Naidu, S. D., Samarasinghe, K., VanHecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. B., Cole, P. A., Ahn, Y. H., Dinkova-Kostova, A. T.  Br. J. Cancer. 2014, 110, 71-82. Link



An Fc Domain Protein-Small Molecule Conjugate as an Enhanced Immunomodulator. Chiang, M. J., Hobert, M. A., Kalin, J. H., Ahn, Y. H., Giddens, J., Amin, M. N., Taylor, M. S., Collins, S. L., Chan-Li, Y., Waickman, A., Hsiao, P. Y., Bolduc, D., Leahy, D. J., Horton, M. R., Wang, L. X., Powell, J. D., Cole, P. A. J. Am. Chem. Soc. 2014, 136, 3370-3373. Link



Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Dancy, B. M., Crump, N. T., Peterson, D. J., Mukherjee, C., Bowers, E. M., Ahn, Y. H., Yoshida, M., Zhang, J., Mahadevan, L. C., Meyers, D. J., Boeke, J. D., Cole, P. A. Chembiochem. 2012, 13, 2113-2121. Link



HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Zhang, Y., Ahn, Y. H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A., Dinkova-Kostova, A. T.  Chem. Biol. 2011, 18, 1355-1361. Link



Development of Neh2-Luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Smirnova, N. A., Haskew-Layton, R. E., Manuela, B., Hushpulian, D. M., Payappilly, J. B., Speer, R. E., Ahn, Y. H., Rakhman, I., Cole, P. A., Pinto, J. T., Ratan, R. R., Gazaryan, I. G. Chem. Biol. 2011, 18, 752-765. Link



Hyaluronan Fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor. Am. J. Respir. Collins, S. L., Black, K. E., Chan-Li, Y., Ahn, Y. H., Cole, P. A., Powell, J. D., Horton, M. R. Cell. Mol. Biol. 2011, 45, 675-683. Link



Bodipy-diacrylate imaging probes for targeted proteins inside live cells. Lee, J. J., Lee, S. C., Zhai, D., Ahn, Y. H., Yeo, H. Y., Tan, Y. L., Chang, Y. T.  Chem. Commun. 2011, 47, 4508-4510. Link



The binding of fluorophores to proteins depends on the cellular environment. Kim, Y. K., Lee, J. S., Bi. X., Ha, H. H., Ng, S. H., Ahn, Y. H., Lee, J. J., Wagner, B. K., Clemons, P. A., Chang, Y. T. Angew. Chem. Int. Ed. Engl. 2011, 50, 2761-2763. Link



Electrophilic tuning of the chemoprotective natural product sulforaphane. Ahn, Y. H., Hwang, Y., Liu, H.; Wang, X. J., Zhang, Y., Stephenson, K. K., Boronina, T. N., Cole, R. N., Dinkova-Kostova, A. T., Talalay, P., Cole, P. A. Proc. Natl. Acad. Soc. USA. 2010, 107, 9590-9595. Link



A fluorescent rosamine compound selectively stains pluripotent stem cells. Im, C. N., Kang, N. Y., Ha, H. H., Bi, X., Lee, J. J., Park, S. J., Lee, S. Y., Vendrell, M., Kim, Y. K., Lee, J. S., Li, J., Ahn, Y. H., Feng, B., Ng, H. H., Yun, S. W., Chang, Y. T. Angew. Chem. Intl. Ed. Engl. 2010, 49, 7497-7500. Link



Combinatorial synthesis of a triphenylmethine library and their application in the development of surface enhanced Raman scattering (SERS) probes. Cho, S. J., Ahn, Y. H., Maiti, K. K., Dinish, U. S., Fu, C. Y., Thoniyot, P., Olivo, M., Chang, Y. T. Chem. Commun. 2010, 46, 722-724. Link



Control of muscle differentiation by a mitochondria-targeted fluorophore. Kim, Y. K., Ha, H. H., Lee, J. S., Bi, X., Ahn, Y. H., Hajar, S., Lee, J. J., Chang, Y. T. J. Am. Chem. Soc. 2010, 132, 576-579. Link



Selective human serum albumin sensor from the screening of a fluorescent rosamine library. Ahn, Y. H., Lee, J. S., Chang, Y. T. J. Combi. Chem. 2008, 10, 376-380. Link



Small molecule fluorophores to detect cell-state switching in the context of high-throughput screening. Wagner, B. K., Carrinski, H., Ahn, Y. H., Kim, Y. K., Gilbert, T. J., Fomina, D., Schreiber, S. L., Chang, Y. T., Clemons, P. A. J. Am. Chem. Soc. 2008, 130, 4208-4209. Link



Styryl-based potential in vivo imaging agents for beta-amyloid plaques. Li, Q., Min, J., Ahn, Y. H., Namm, J., Kim, E. M., Lui, R., Ji, Y., Wu, Z. H., Wisniewski, T., Chang, Y. T. Chembiochem 2007, 8, 1679-1687. Link



Combinatorial synthesis of dapoxyl dyes and application to site-selective probe for human serum albumin. Min, J., Lee, J. W., Ahn, Y. H., Chang, Y. T. J. Combi. Chem. 2007, 9, 1079-1083. Link



Tagged small molecule library approach for facilitated chemical genetics. Ahn, Y. H., Chang, Y. T. Acc. Chem. Res. 2007, 40, 1025-1033. Link



Combinatorial rosamine library and application to in vivo glutathione probe. Ahn, Y. H., Lee, J. S., Chang, Y. T. J. Am. Chem. Soc. 2007, 129, 4510-4511. Link



RNA-selective, live cell imaging probes for studying nuclear structure and function. Li, Q., Kim, Y. K., Namm, J., Kulkarni, A., Rosania, G., Ahn, Y. H., Chang, Y. T. Chem. Biol. 2006, 13, 615-623. Link



Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. Chi, Y., Zhou, B., Wang, W. Q., Chung, S. K., Kwon, Y. U., Ahn, Y. H., Chang, Y. T., Tsujishita, Y., Hurley, J. H., Zhang, Z. Y.  J. Biol. Chem. 2004, 279, 44987-44995. Link



Molecular evolution using intramolecular acyl migration on myo-inositol benzoates with thermodynamic and kinetic selectors. Ahn, Y. H., Chang, Y. T. Chem. Eur. J. 2004, 10, 3543-3547. Link



Molecular evolution on chiro-inositol dibenzoate using intramolecular acyl migration and selection by phenyl boronic acid. Ahn, Y. H., Chang, Y. T.  J. Combi. Chem. 2004, 6, 293-296. Link



A study on the effect of lanthanide ion coordination on the stereoselective synthesis of β-mannopyranosides. Ahn, Y. H., Chung, S. K. Kor. Chem. Soc. 2003, 24, 116-118. Link



A study of benzene 1,2,4-trisphosphate derivatives as inositol 1,4,5-trisphosphate 3-kinase inhibitors. Ahn, Y. H., Chung, S. K.  Kor. Chem. Soc. 2002, 23, 515-517. Link



A novel DAST-induced debenzylative cycloetherization in D-1,2-O-isopropylidene-3,4,5-tri-O-benzyl-myo-inositol. Chung, S. K., Kwon, Y. U., Ahn, Y. H., Jeong, T. H., Chang, Y. T.  Kor. Chem. Soc. 2000, 21, 274-276. Link

bottom of page