top of page
Publication 2.jpg



Emerging Chemistry and Biology in Protein Glutathionylation. Kukulage, D. S. K., Matarage Don, N. N. J., Ahn, Y. H.* Curr. Opin. Chem. Biol. 2022, accepted

Read the Paper
Graphical Abstract.tif

Bach derepression is neuroprotective in mouse model of Parkinson’s disease, Ahuja, M., Kaidery, N. A., Attucks, O. C., McDade, E., Hushpulian, D. M., Gaisin, A., Gaisina, I., Ahn, Y. H., Nikulin, S., Poloznikov, A., Gazaryan, I., Yamamoto, M., Matsumoto, M., Igarashi, K., Sharma, S. M. Thomas, B. , Proc. Natl. Acad. Sci. USA. 2021, 118, e2111643118


Identification and Quantification of Glutathionylated Cysteines under Ischemic Stress, Yapa Abeywardana, M., Samarasinghe, K. T. G., Munkanatta Godage, D., Ahn, Y. H. J. Proteome Res. 202120, 4529-4542.

Graphical Abstract.jpg

Titin N2A Domain and Its Interactions at the Sarcomere, Adewale, A. O., Ahn, Y. H. Int. J. Mol. Sci. 2021, 22, 7563


Synthesis and Evaluation of Tiaprofenic Acid-derived UCHL5 Deubiquitinase Inhibitors, Gurusingha Arachchige, H. S., Herath Mudiyanselage, P. D. H., VanHeck, G. C., Patel, K., Cheaito, H. A., Dou, Q. P., Ahn, Y. H. Bioorg. Med. Chem202130, 115931

Graphical Abstract.tif

Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells, Zhang, Y., VanHecke, G. C., Ahn, Y. H., Proby, C. M., Dinkova-Kostova, A. T. Eur. J. Pharmacol2020889, 173609


Isotopically-labelled Clickable Glutathione to Quantify Protein S-Glutathionylation, VanHecke, G. C.,ª Yapa Abeywardana, M.,ª Huang, B., Ahn, Y. H. ChemBioChem202021, 853-859. ªequal contribution


The isothiocyanate sulforaphane inhibits mTOR in an Nrf2-independent manner, Zhang, Y., Gilmour, A., Ahn, Y. H., de la Vega, L., Dinkova-Kostova, A. T. Phytomedicine 2021, 86, 153062


Proteomic Identification of Protein Glutathionylation in Cardiomyocytes, VanHecke, G. C., Yapa Abeywardana, M., Ahn, Y. H. J. Proteome Res. 2019, 18, 1806-1818.


Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds, Castro, I., Ekinic, E., Huang, X., Cheaito, H. A., Ahn, Y. H., Olivero-Verbel, J., Dou, Q. P. J. Cell. Biochem. 2019120, 14065-14075


SMYD2 Glutathionylation Contributes to Degradation of Sarcomeric Proteins. Munkanatta Godage, D. N. P., VanHecke, G. C., Samarasinghe, K. T. G., Feng, H. Z., Hiske, M., Holcomb, J., Yang, Z., Jin, J. -P., Chung, C. S., Ahn, Y. H.  Nature Commun20189, 4341.


Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition. Patel, K., Ahmed, Z. S. O., Huang, X., Yang, Q., Barzegar, E. E., Neslund-Dudas, C. M., Mitra, B., Elnady, F. A. E. M., Ahn, Y. H., Yang, H., Liu, J., Dou, Q.  Future Med. Chem. 201810, 2087-2108.


Redox-inactive peptide disrupting Trx1-Ask1 interaction for selective activation of stress signaling. Kekulandara, D. N., Nagi, S., Seo, H., Chow, C. S., Ahn, Y. H.  Biochemistry 201857, 772–780.

Dilini Biochem.jpg

Sphingosine-1-phosphate receptor subtype 3 regulates TGF-β-mediated Sani1/E-cadherin pathway and lung adenocarcinoma progression. Zhao, J., Liu, J., Lee, J. F., Zhang, W., VanHecke, G. C., Gartung, A., Gauldie, J., Ahn, Y. H., Lee, M. J.  J. Biol. Chem. 2016, 291, 27343-27353.


Clickable glutathione using tetrazine-alkene bioorthogonal chemistry for detecting protein glutathionylation. Kekulandara, D. N., Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Ahn, Y. H. Org. Biomol. Chem. 201614, 10886-10893. 

Dilini OBC.jpg

J. Characterization of eicosanoids produced by adipocyte lipolysis: implication of cyclooxygenase-2 in adipose inflammation. Gartung, A., Zhao, J., Chen, S., Mottillo, E., VanHecke, G. C., Ahn, Y. H., Maddipati, K. R., Sorokin, A., Granneman, J., Lee, M.  J. Biol. Chem. 2016291, 16001-16010. 


Identification of protein glutathionylation in response to glucose metabolism. Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Zhou, Y., Ndombera, F. T., Weerapana, E., Ahn, Y. H. Mol. Biosyst. 201612, 2471-2480. 

Mol Biosyst.jpg

Carbohydrate-based Inducers of Cellular Stress for Targeting Cancer Cells. Ndombera, F. T., VanHecke, G. C., Nagi, S., Ahn, Y. H. Bioorganic. Med. Chem. Lett. 201626, 1452-1456.


YcgC Represents a New Protein Deacetylase Family in Prokaryote. Tu, Shun., Guo, S. J., Chen, C. S., Liu, C. X., Jiang, H. W., Ge, F., Deng, J. Y., Zhou, Y. M., Czajkowsky, D., Li, Y., Cole, P. A., Ahn, Y. H., Zhu, H., Tao, S. C.  eLife20154, e05322.


Synthesizing Clickable Glutathione by Glutathione Synthetase Mutant for Detecting Protein Glutathionylation. Samarasinghe, K. T. G., Ahn, Y. H.  SynLett201526, 285-293.


A Versatile New Tool to Label Abasic Sites in DNA and Inhibit Base Excision Repair.  Wei, S., Shalhout, S., Ahn, Y. H., Bhagwat, A. S. DNA Repair2015, 27, 9-18.


Adipocyte Lipolysis-stimulated Interleukin-6 Production Regulates Sphingosine Kinase 1 Activity. Zhang, W., Mottillo, E. P., Zhao, J., Gartung, A., VanHecke, G. C., Lee, J. F., Maddipati, K. R., Xu, H., Ahn, Y. H., Prola, R. L., Granneman, J. G., Lee, M. J.  J. Biol. Chem2014289, 32178-32185.


Metabolic Synthesis of Clickable Glutathione for Chemoselective Detection of Glutathionylation, Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., VanHecke, G. C., Ahn, Y. H.  J. Am. Chem. Soc. 2014, 136, 11566-11569. 


Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. Zhang, Y., Naidu, S. D., Samarasinghe, K., VanHecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. B., Cole, P. A., Ahn, Y. H., Dinkova-Kostova, A. T.  Br. J. Cancer. 2014, 110, 71-82.


An Fc Domain Protein-Small Molecule Conjugate as an Enhanced Immunomodulator. Chiang, M. J., Hobert, M. A., Kalin, J. H., Ahn, Y. H., Giddens, J., Amin, M. N., Taylor, M. S., Collins, S. L., Chan-Li, Y., Waickman, A., Hsiao, P. Y., Bolduc, D., Leahy, D. J., Horton, M. R., Wang, L. X., Powell, J. D., Cole, P. A. J. Am. Chem. Soc2014136, 3370-3373.


Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Dancy, B. M., Crump, N. T., Peterson, D. J., Mukherjee, C., Bowers, E. M., Ahn, Y. H., Yoshida, M., Zhang, J., Mahadevan, L. C., Meyers, D. J., Boeke, J. D., Cole, P. A. Chembiochem. 2012, 13, 2113-2121.


HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Zhang, Y., Ahn, Y. H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A., Dinkova-Kostova, A. T.  Chem. Biol. 201118, 1355-1361.


Development of Neh2-Luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Smirnova, N. A., Haskew-Layton, R. E., Manuela, B., Hushpulian, D. M., Payappilly, J. B., Speer, R. E., Ahn, Y. H., Rakhman, I., Cole, P. A., Pinto, J. T., Ratan, R. R., Gazaryan, I. G. Chem. Biol. 201118, 752-765.


Hyaluronan Fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor. Am. J. Respir. Collins, S. L., Black, K. E., Chan-Li, Y., Ahn, Y. H., Cole, P. A., Powell, J. D., Horton, M. R. Cell. Mol. Biol. 201145, 675-683.


Bodipy-diacrylate imaging probes for targeted proteins inside live cells. Lee, J. J., Lee, S. C., Zhai, D., Ahn, Y. H., Yeo, H. Y., Tan, Y. L., Chang, Y. T.  Chem. Commun. 201147, 4508-4510. 


The binding of fluorophores to proteins depends on the cellular environment. Kim, Y. K., Lee, J. S., Bi. X., Ha, H. H., Ng, S. H., Ahn, Y. H., Lee, J. J., Wagner, B. K., Clemons, P. A., Chang, Y. T. Angew. Chem. Int. Ed. Engl. 201150, 2761-2763.


Electrophilic tuning of the chemoprotective natural product sulforaphane. Ahn, Y. H., Hwang, Y., Liu, H.; Wang, X. J., Zhang, Y., Stephenson, K. K., Boronina, T. N., Cole, R. N., Dinkova-Kostova, A. T., Talalay, P., Cole, P. A. Proc. Natl. Acad. Soc. USA2010107, 9590-9595.


A fluorescent rosamine compound selectively stains pluripotent stem cells. Im, C. N., Kang, N. Y., Ha, H. H., Bi, X., Lee, J. J., Park, S. J., Lee, S. Y., Vendrell, M., Kim, Y. K., Lee, J. S., Li, J., Ahn, Y. H., Feng, B., Ng, H. H., Yun, S. W., Chang, Y. T. Angew. Chem. Intl. Ed. Engl. 201049, 7497-7500.


Combinatorial synthesis of a triphenylmethine library and their application in the development of surface enhanced Raman scattering (SERS) probes. Cho, S. J., Ahn, Y. H., Maiti, K. K., Dinish, U. S., Fu, C. Y., Thoniyot, P., Olivo, M., Chang, Y. T. Chem. Commun201046, 722-724.


Control of muscle differentiation by a mitochondria-targeted fluorophore. Kim, Y. K., Ha, H. H., Lee, J. S., Bi, X., Ahn, Y. H., Hajar, S., Lee, J. J., Chang, Y. T. J. Am. Chem. Soc2010132, 576-579. 


Selective human serum albumin sensor from the screening of a fluorescent rosamine library. Ahn, Y. H., Lee, J. S., Chang, Y. T. J. Combi. Chem200810, 376-380.


Small molecule fluorophores to detect cell-state switching in the context of high-throughput screening. Wagner, B. K., Carrinski, H., Ahn, Y. H., Kim, Y. K., Gilbert, T. J., Fomina, D., Schreiber, S. L., Chang, Y. T., Clemons, P. A. J. Am. Chem. Soc2008130, 4208-4209.


Styryl-based potential in vivo imaging agents for beta-amyloid plaques. Li, Q., Min, J., Ahn, Y. H., Namm, J., Kim, E. M., Lui, R., Ji, Y., Wu, Z. H., Wisniewski, T., Chang, Y. T. Chembiochem 20078, 1679-1687.


Combinatorial synthesis of dapoxyl dyes and application to site-selective probe for human serum albumin. Min, J., Lee, J. W., Ahn, Y. H., Chang, Y. T. J. Combi. Chem20079, 1079-1083.


Tagged small molecule library approach for facilitated chemical genetics. Ahn, Y. H., Chang, Y. T. Acc. Chem. Res200740, 1025-1033.


Combinatorial rosamine library and application to in vivo glutathione probe. Ahn, Y. H., Lee, J. S., Chang, Y. T. J. Am. Chem. Soc2007129, 4510-4511.


RNA-selective, live cell imaging probes for studying nuclear structure and function. Li, Q., Kim, Y. K., Namm, J., Kulkarni, A., Rosania, G., Ahn, Y. H., Chang, Y. T. Chem. Biol. 200613, 615-623.


Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. Chi, Y., Zhou, B., Wang, W. Q., Chung, S. K., Kwon, Y. U., Ahn, Y. H., Chang, Y. T., Tsujishita, Y., Hurley, J. H., Zhang, Z. Y.  J. Biol. Chem2004279, 44987-44995.


Molecular evolution using intramolecular acyl migration on myo-inositol benzoates with thermodynamic and kinetic selectors. Ahn, Y. H., Chang, Y. T. Chem. Eur. J200410, 3543-3547.


Molecular evolution on chiro-inositol dibenzoate using intramolecular acyl migration and selection by phenyl boronic acid. Ahn, Y. H., Chang, Y. T.  J. Combi. Chem20046, 293-296.


A study on the effect of lanthanide ion coordination on the stereoselective synthesis of β-mannopyranosides. Ahn, Y. H., Chung, S. K. Kor. Chem. Soc200324, 116-118


A study of benzene 1,2,4-trisphosphate derivatives as inositol 1,4,5-trisphosphate 3-kinase inhibitors. Ahn, Y. H., Chung, S. K.  Kor. Chem. Soc. 200223, 515-517


A novel DAST-induced debenzylative cycloetherization in D-1,2-O-isopropylidene-3,4,5-tri-O-benzyl-myo-inositol. Chung, S. K., Kwon, Y. U., Ahn, Y. H., Jeong, T. H., Chang, Y. T.  Kor. Chem. Soc. 200021, 274-276

bottom of page